Chiral separations on polysaccharide stationary phases using polar organic mobile phases
نویسندگان
چکیده
منابع مشابه
Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases
In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...
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The direct enantioseparation of a novel aminothiazolecarboxamide fungicide, ethaboxam, on polysaccharide-derived chiral stationary phases (CSPs) is described. Good resolution is achieved with several polysaccharide-derived CSPs. Chiralcel OD (OD-H) and Chiralpak AS are excellent for direct enantiomer separation of ethaboxam. The elution behavior and the effects of eluent composition on the reso...
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Since their introduction on the market the applicability of immobilized polysaccharide-based chiral stationary phases in high-performance liquid chromatography has been thoroughly investigated. These immobilized phases have the benefit to be applicable with a wide range of modifiers, potentially extending the application range of the polysaccharide-based stationary phases. Because an increasing...
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Separation of the enantiomers of linezolid has been compared on derivatized cellulose and amylose chiral stationary phases (Chiracel OD and Chiralpak AD) with mixtures of hexane with 1-propanol, 2-propanol, or ethanol as mobile phases. It was found that use of a small amount of water as mobile phase additive can improve or prevent enantioseparation, depending on the column. The order of elution...
متن کاملPolar stationary phases for capillary electrochromatography.
This review article summarizes the variety of polar stationary phases that have been employed for capillary electrochromatographic separations. Compared with reversed-phase stationary phases, the polar alternatives provide a completely different retention selectivity towards polar and charged analytes. Different types of polar stationary phases are reviewed, including the possible retention mec...
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ژورنال
عنوان ژورنال: Chirality
سال: 2005
ISSN: 0899-0042,1520-636X
DOI: 10.1002/chir.20212